- Preparation and Release characteristics of Indomethacin and Diclofenac Sodium Solid-Emulsion Gels
Pages 36-57, Mans. J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z.El-Shaboury et al
- The use of binary and ternary mixtures of magnesium stearate, talc and colloidal silica for preparing sustained release tablets of a high loading dose drug
Pages 1283-1288, Pharm. Ind
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-shaboury
- Nanoparticles for improving the dissolution and oral bioavailability of carbamazepine
Pages 1-14, The 6th Scientific Congress of the Association of Colleges of Pharmacy in the Arab World, Ajman, United Arab Emirates
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Positively charged nanoparticles for improving the oral bioavailability of cyclosporin A
Pages 101-109, Int. J. Pharm
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-shaboury
- Nanoparticles for improving the dissolution and bioavailability of spironolactone, a poorly-soluble drug
Pages 97-102, S.T.P. Pharma Sciences
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Enhancement of dissolution and bioavailability of piroxicam via solid dispersion with phospholipids
Pages 309-321, Bull. Fac. Pharm. Cairo Univ
أ.د. محمد حامد زكى الشابورى
M.H.Z.El-Shaboury et al
- Preparation and physicochemical characterization of solid dispersions of piroxicam with phospholipids
Pages 299-313, Bull. Fac. Pharm. Cairo Univ
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Preparation and evaluation of diclofenac zinc and bismuth salts with minimal gastro-intestinal side effect
Pages 82-98, Mans. J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Enhanced systemic bioavailability of intravenous and rectal piroxicam in rabbits following oral administration of chenodeoxycholic acid
Pages 211-216, S.T.P., Pharma Sciences
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Evaluation and tableting characterization of spironolactone-B-cyclodextrin complex prepared by double compression
Pages 47-62, Mans. J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Effect of co-grinding of insoluble drugs with ?-cyclodextrin on their solubility and bioavailability
Pages 111-127, Drug Dev. Ind. Pharm
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Stability and bioavailability of diclofenac sodium dry adsorbed emulsions
Pages 212-226, J. Bio. Med. Sci. Ther
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Stability of Digestive Enzymes in Formulated and Commercial Tablets
Pages 33-46, Mans. J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Sustained release of diclofenac sodium from dry adsorbed emulsions
Pages 1-17, Mans. J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Effect effervescent salt on the dissolution and bioavailability of drugs from capsules filled on a dosator-type capsules-filling machine
Pages 176-180, Pharm. Ind
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Dissolution behavior and bioavailability of indomethacin from solid dispersion systems prepared with egg albumin
Pages 45-61, J. Bio. Med. Sci., Ther
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Formulation , bioavailability and toxicity of phenobarbitone alcohol-free elixirs
Pages 61-78, J. Bio. Med. Sci., Ther
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Formulation of hydroflumethiazide dispersible tablets
Pages 7-12, Alexandria J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Use of factorial design for the evaluation of the chemical stability of aspirin tablets
Pages 129-134, Alexandria J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Formulation and release kinetics of sustained release peppermint oil granules for treatment of irritable bowel syndrome
Pages 645-648, Pharm. Ind.
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Combining coprecipitation and solvent deposition on tablet formulation
Pages 119-125, Alexandria J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Formulation and ocular disposition of bromhexine HCl ophthalmic preparations
Pages 224-239, Mans. J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Formulation and release characteristics of phenylepherine HCl suppositories
Pages 259-270, Mans. J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- In-vitro and in vivo evaluation of sustained release Floctafenine granules
Pages 239-259, Mans. J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Dissolution profiles, bioavailability and gastric irritation of indomethacin-milk coprecipitates
Pages 175-190, J. Bio. Med. Sci. Ther
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Formulation, stability and bioavailability of paracetamol elixiris free from ethyl alcohol
Pages 288-303, J. Bio. Med. Sci. Ther
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Application of factorial design of experiments to predict the chemical stability of ferrous fumarate and thiamine HCl tablets
Pages 130-147, Mans. J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Chemical stability of thiamine HCl and ferrous fumarate tablets prepared by direct and wet granulation technique
Pages 111-129, Mans. J. Pharm
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Effect of stress storage conditions on the physical characteristics and dissolution profiles of thiamine HCL and ferrous fumarate tablets
Pages 102-126, Mans.J. Pharm. Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Preparation of thiamine HCL and ferrous fumarate tablets prepared by direct granulation technique
Pages 36-51, Mans. J. Pharm .Sci
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Physical and chemical stability of phenobarbitone and diazepam tablets directly compressed with ?-cyclodextrin
Pages 1-12, The Third Kuwait Pharmaceutical Conference
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Stability of spironolactone tablets prepared with ?-cyclodextrin
Pages 13-23, The Third Kuwait Pharmaceutical Conference
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Bioavailability of prednisolone and spironolactone from fresh and aged tablets directly compressed with ?-cyclodextrin
Pages 30-39, The Third Kuwait Pharmaceutical Conference
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Physical properties and dissolution profiles of tablets directly compressed with ?-cyclodextrin
Pages 95-101, Int. J. Pharm
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Effect of surfactant treated diluents on the dissolution and bioavailability of frusemide from capsules and tablets
Pages 253-260, Acta Pharm. Fenn
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Effect of tablet shape on the in vitro and in vivo availability of directly compressed, non –disintegrating tablets
Pages 694-699, Pharm. Ind
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Application of agglomerative phase of comminution method for the preparation of phenylbutazone and vitamin B1 tablets
Pages 1199-1204, Pharm. Ind
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury
- Influence of technique of tablet making on the in vitro and in vivo availability of acetyl salicylic acid tablets
Pages 66-70, Pharm. Ind
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Physical properties and stability of diazepam and phenobaritone sodium tablets prepared with compactrol
Pages 1947-1958, Drug Devel. Ind .Pharm
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Factors controlling measurement of the crushing strength of calcium sulfate granules evaluated by ball mill
Pages 1-18, Bull. Pharm. Sci., Assuit University
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Controlled release of Pancreatic Enzymes
Pages 1-4, Proceed Intern. Symp. Control, Rel. Bioact. Mater, Germany
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Effect of certain tablet ingredients on the penetration rate of powder beds
Pages 125-139, Proceed, 1st International Conference of Applied Sciences, Zagazig University
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Controlled release nicotinic acid tablets
Pages 1-15, Proceed 1st International Conference of Applied Sciences, Zagazig University
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Penetration of liquids into powder beds
Pages 16-31, Proceed, 1st International Conference of Applied Sciences, Zagazig University
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Release of glafenine and glafenine HCL from ointment bases
Pages 1-14, Proceed, 1st International Conference of Applied Sciences , Zagazig University
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Comparative study on the Physico-chemical stability of acetylsalicylic acid tablets prepared by microencapsulaton and other preparative technique
Pages 25-47, Bull. Pharm. Sci., Assiut University
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Evaluation and bioavailability of phenazopyridine HCL tablets prepared with compactrol
Pages 1-16, Bull. Pharm .Sci. Assuit University
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Formulation of infantile ephedrine HCL suppositories; Physico-chemical and release characteristics
Pages 143-151, Bull. Pharm .Sci. Assuit University
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Bioavailability of effervescent tablets containing phenylbutazone
Pages 1-5, Proceed 2nd European congress of Biopharmaceutics and Pharma-cokinetics, Spain, 1984
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- The use of directly compressible vehicles for the preparation of vitamin B1 tablets
Pages 247-250, Pharmazie
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Evaluation of tablets prepared by agglomerative phase of comminution method
Pages 201-207, Acta Pharm. Fenn
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Effect of surfactant treated binder on the physical properties and bioavailability of sulfadiazine tablets
Pages 43-48, Acta Pharm. Technol
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Enhanced dissolution rate of ibuprofen using surfactants and water soluble carriers
Pages 2-12, Bull. Pharm .Sci. Assuit University
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- - Influence of microcapsule size on the bioavailability of acetylsalicylic acid from ethyl cellulose microcapsules
Pages 221-227, J.Drug Research
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Physical properties and dissolution profiles of acetaminophen and acetylsalicylic acid tablets made from sucrose-based vehicles
Pages 488-492, Pharmazie
أ.د. محمد حامد زكى الشابورى
M.H.Z. El-Shaboury et al
- Potential use of ?-cyclodextrin polypseudorotaxane hydrogels as an injectable sustained release system for insulin.
Pages 83-91, International Journal of Pharmaceutics, يناير 2010
ارهان ابراهيم أبو هاشم محمد
Borg Th. M.
Abd El-Gawad H. Abd El-Gawad
أ.د. محمد حامد زكى الشابورى
Taishi Higashi,Takayuki Anno,Keiichi Motoyama,Hidetoshi Arima
- Potential use of iontophoresis for transdermal delivery of NF-kB decoy oligonucleotides
Pages 127-134, International Journal of Pharmaceutics, يناير 2010
ارهان ابراهيم أبو هاشم محمد
Borg Th. M.
Abd El-Gawad H. Abd El-Gawad
أ.د. محمد حامد زكى الشابورى
Keiichi Motoyama,Hidetoshi Arima
- Formulation and evaluation of a buccoadhesive captopril tablets
Bull. Pharm. Sci. Assiut University. Vol. 32, Part 1
Osama A. Soliman
أ.د. حمدى محمد عبد العليم السيد
أ.د. محمد حامد زكى الشابورى
M. S. El-dahhan
Abstract Abstract Formulation and evaluation of a buccoadhesive captopril tablets Buccoadhesive tablets of captopril were prepared by direct compression of the drug with different polymers; Carbopol 934 (CP 934), Eudragit RS 100 (EU RS 100), Chitosan (Ch), Hydroxpropyl methylcellulose (HPMC) and Polyvinylpyrrolidone K30 (PVP K30) either singly or in blends of different ratios. The tablets were evaluated for their weight variation, drug content uniformity, friability, hardness, swelling index, surface pH, in-vitro bioadhesive strength and release characteristics. The bioavailability and the pharmacokinetics parameters of captopril from two selected formulations (CP 934:HPMC 6:4 and Ch:HPMC 6:4) were evaluated.
The in-vitro bioadhesive strength and release characteristics were found to be a function of the type of polymer, ratio of polymer blends. Swelling and bioadhesive characteristics were determined for both plain and medicated tablets. The high concentration of carbopol and chitosan containing formulations showed the greatest adhesive strength. The mean pharmacokinetic parameters of captopril after buccoadhesive tablet administration were: Cmax 506.9 ng/ml, Tmax 4 hr, AUC0-8 2359.5 ng.hr/ml for CP 934: HPMC (6:4), while Cmax 429.02 ng/ml, Tmax 2.67 hr, AUC0-8 1637.43 ng.hr/ml for Chitosan: HPMC (6:4). In comparison, in case of oral administration of control tablet the Cmax 591.28 ng/ml, Tmax 1.5 hr, AUC0-8 1869.29 ng.hr/ml .
- Formulation and Evaluation of Self-Emulsifying Systems Containing Indomethacin
The Egyptian American Scholars 35th International Annual Conference, 27-29 December, 2008
Abd El-Gawad H. Abd El-Gawad
أ.د. محمد حامد زكى الشابورى
محمد مصطفى ابراهيم مصطفى
Abstract Abstract Formulation and Evaluation of Self-Emulsifying Systems Containing Indomethacin Several self-emulsifying systems with various compositions were prepared
using different oils such as soybean oil, coconut oil and ethyl oleate in different
concentration with various surfactants such as tween 80 and / or brij 30 in
different ratios with or without semipolar organic solvent such as absolute ethyl
alcohol, propylene glycol and polyethylene glycol 400 in different ratios. The
obtained systems were subjected to several evaluation tests to select the most
stable SES. Four stable SESs were selected for the subsequent studies.
Indomethacin was incorporated in the selected SESs in a concentration of 5 %
in formulae I, II & III and 2.5 % in formula IV. The prepared SESs containing
indomethacin were evaluated for; phase separation, pH determination and
uniformity of drug content. The SES formulations were subjected to stability
study at different temperatures; 40, 50, 60 oC and at room temperature (25 oC)
for six months. Bioavailability of indomethacin from formula II was studied on
six healthy male volunteers and compared to control capsules containing
indomethacin alone. The obtained results revealed that, generally, SES
formulations were greatly improved in vitro and in vivo releases as well as the
stability of poorly water soluble drugs. The bioavailability value showed more
than two fold increases (203.18%), suggesting that the oral absorption of
indomethacin is greatly improved by SES.
- Formulation and Evaluation of Self-Emulsifying Systems Containing Piroxicam
The Egyptian American Scholars 35th International Annual Conference, 27-29 December, 2008
Abd El-Gawad H. Abd El-Gawad
أ.د. محمد حامد زكى الشابورى
محمد مصطفى ابراهيم مصطفى
Abstract Abstract Formulation and Evaluation of Self-Emulsifying Systems Containing Piroxicam Several self-emulsifying systems (SESs) with various compositions
were prepared using different oils such as soybean oil, coconut oil and ethyl
oleate in different ratios with various surfactants such as tween 80 and / or brij
30 in different concentrations with or without semipolar organic solvent such as
absolute ethyl alcohol, propylene glycol and polyethylene glycol 400 in different
ratios. The obtained systems were subjected to several evaluations to select
the most stable SES. Four stable SESs were selected for the subsequent
studies. Piroxicam was incorporated in the selected SESs in a concentration of
5 % in formulae I, II & III and 2.5 % in formula IV. The prepared SESs
containing piroxicam were evaluated for; phase separation, pH determination
and uniformity of drug content. The SES formulations were subjected to stability
study at different temperatures; 40, 50, 60 oC and at room temperature (25 oC)
for six months. The obtained results revealed that, SES formulations were
greatly improved in vitro releases as well as the stability of poorly water soluble
drugs.
- FORMULATION AND EVALUATION OF SUSTAINED RELEASE ASCORBIC
ACID TABLETS
The Egyptian American Scholars 35th International Annual Conference, 27-29 December, 2008
سلمى مؤنس المغازى المرسى سلطان
Abd El-Gawad H. Abd El-Gawad
أ.د. محمد حامد زكى الشابورى
Abstract Abstract FORMULATION AND EVALUATION OF SUSTAINED RELEASE ASCORBIC
ACID TABLETS In this study, sustained-release tablets of a high loading-dose drug were
prepared using small concentrations of dissolution retardant materials which
can not affect the final weight or bulkness of the formulation design.
Accordingly, ascorbic acid was selected as an example of high loading-dose
drug to prepare sustained-release tablets using binary mixtures of hydrophobic
retardants such as magnesium stearate, stearic acid and talc in different ratios.
The results obtained revealed that using 6% w/w magnesium stearate alone
reflected adverse negative effects on the mechanical properties of the produced
tablets. However, these deteriorating effects were less pronounced in case of
using 6% w/w binary mixtures of magnesium stearate, stearic acid and talc at
different ratios. Tablets prepared using 6% w/w magnesium stearate alone
showed higher release rate than in case of using 6% w/w binary mixtures of
magnesium stearate and talc. On the contrast, they showed lower release rate
than those prepared with 6% w/w binary mixtures of stearic acid and talc.
Finally, they showed intermediate release rate between those prepared using
6% w/w binary mixtures of magnesium stearate and stearic acid at different
ratios. Release rate mechanism of ascorbic acid from each tested formula was
a combination of two mechanisms, Higuchi model followed by first order except
for the control formulations the best fitting was first order followed by Higuchi
model, in which one is more predominant than the other.
- FORMULATION AND EVALUATION OF TABLETS CONTAINING HIGH
LOADING DOSE DRUG
The Egyptian American Scholars 35th International Annual Conference, 27-29 December, 2008
سلمى مؤنس المغازى المرسى سلطان
Abd El-Gawad H. Abd El-Gawad
أ.د. محمد حامد زكى الشابورى
Abstract Abstract FORMULATION AND EVALUATION OF TABLETS CONTAINING HIGH
LOADING DOSE DRUG In this study, sustained-release tablets of a high loading-dose drug were
prepared using small concentrations of dissolution retardant materials which
can not affect the final weight or bulkness of the formulation design.
Accordingly, paracetamol was selected as a model of high loading-dose drugs
to prepare sustained-release tablets using binary mixtures of hydrophobic
lubricants such as magnesium stearate, stearic acid and talc in different ratios.
The results obtained revealed that using 6% w/w magnesium stearate alone
reflected adverse negative effects on the mechanical properties of the produced
tablets. Tablets prepared using 6% w/w magnesium stearate alone showed
higher release rate than in case of using 6% w/w binary mixtures of magnesium
stearate and talc. On the contrast, they showed lower release rate than those
prepared with 6% w/w binary mixtures of stearic acid and talc. Release rate
mechanism of paracetamol from each prepared formula was a combination of
two mechanisms, first order model followed by Higuchi model or zero order
except for the control formulation (F1) the best fitting was Higuchi equation
followed by first order or zero order, in which one is more predominant than the
other. Bioavailability study of paracetamol from prepared tablets in healthy
human volunteers revealed that, tablets containing magnesium stearate, stearic
acid and talc binary mixture in ratio of 5:1 (F4 and F6) showed higher
bioavailability and more efficient sustained-release effect than the control
tablets. However, the more suitability of F4 than F6 as a sustained-release
system was also observed. This indicated by low Cmax values and high AUC
values comparing to the control tablets.
- Preparation and Release Characteristics of Indomethacin and Diclofenac Sodium Solid- Emulsion Gels.
Pages 36-56
Abdelghani G.M.
أ.د. خيرى السيد جبر جبر
Mohamed E.E.Shams
أ.د. محمد حامد زكى الشابورى
Abstract Abstract Preparation and Release Characteristics of Indomethacin and Diclofenac Sodium Solid- Emulsion Gels. solid-emulsion gels in the form of granules, beads discs containing 2.5 and 5% w/w of indomethacin (IM) or Diclofenac sodium (DFS) were prepared the aqueous phase was gelatin solution in concentration of 10, 15 or 20 % w/w of the emulsion the oily phase was castor oil (10% w/w), stearic acid or beeswax (10, 15 or 20% w/w)
the sustained release pattern of IM& DFS from different pharmaceutical forms can be arranged in the following order: discs< beads< granules.
the amount of drug released per unit time form all formulae containing 5% w/w drug were more than those containing 2.5%w/w. the drug realsewas significantly decreased by either increasing the percentage of the oil phase or by the use of oily phase. this profiles can be arranged in the following order: beewax < stearic < acid < castor oil, at least two mathematical models can adequately describe the whle release kinetics situation.
- Preparation and Evaluation of Diclofenac Zinc and Bismuth Salts with Minimal Gastro-Intestinal Side Effects
Pages 82-97, جامعه المنصورة -كلية الصيدلة
Borg Th. M.
أ.د. محمد حامد زكى الشابورى
Abstract Abstract Preparation and Evaluation of Diclofenac Zinc and Bismuth Salts with Minimal Gastro-Intestinal Side Effects Abstract
Both zinc and bismuth salts of diclofenac were prepared and characterized by IR and DSC. The pH-solubility profile at 25°C, in-vitro release patterns at 37nC by dissolution method and ulcerogenicity was determined for the prepared zinc and bismuth salts and compared with diclofenac sodium. The results reveaied that, solubility of these salts was increased by pH elevation. The release of diclofenac zinc and bismuth salts showed a sustained release profile, since about 50 and 55% of the drug was released after 6-hour dissolution from bismuth and zinc salt respectively.
The prepared salts showed no hyperemia or gastric ulcer in animals which indicated that diclofenac salts with zinc or bismuth protects the stomach against gastric irritation and damage. Accordingly, this study is considered as a feasible approach in giving the drug with minimum side effects.
- Evaluation and tableting characterization of spironolactone -0-cyclodextrin complex prepared by double compression technique
Pages 46-60, جامعة المنصورة - كلية الصيدلة
أ.د. حمدى محمد عبد العليم السيد
أ.د. خيرى السيد جبر جبر
أ.د. محمد حامد زكى الشابورى
Abstract Abstract Evaluation and tableting characterization of spironolactone -0-cyclodextrin complex prepared by double compression technique In this study, double compression technique (slugging) was evaluated to prepare SP-BCD complex. The prepared complex m evaluated by infrared (IR) and X-ray diffraction and compared with solid state complexes prepared from aqueous solution and partitioning technique. The SP-BCD powders were formulated into tablets and evaluated for their physico-chemical properties
The aqueous solubility of SP from the prepared complexes and physical mixtures was found to be similar. The IR and X-ray diffracra studies of SP-BCD slugs indicated the presence of a mixture of amorphous, crystalline and inclusion complex. The tablet properts showed variations in hardness and disintegration time values, dissolution rate of SP from tablets containing slugs is similar to those containing the other SP-BC complexes while tablets prepared without! BCD showed a very slow dissolution rate.
- STABILITY OF DIGESTIVE ENZYMES IN THE FORMULATED AND
COMMERCIAL TABLETS
Pages 31-43, كلية الصيدلة - جامعة المنصورة, 23/11/1992
أ.د. أحمد طلعت ابراهيم نوح
أ.د. عبد الحليم حسين غانم
أ.د. محمد حامد زكى الشابورى
أ.د. يسرى السعيد محمد ابراهيم
Abstract Abstract STABILITY OF DIGESTIVE ENZYMES IN THE FORMULATED AND
COMMERCIAL TABLETS The stability of amylase and lipase in formulated panc-eatin tablets prepared by direct compression using Avicel PH
1 and zeparox were studied at four temperatures (50°, 37 ,
- o
and 4 C) for 6 months. Pancreatin-Avicel tablet coated
th HPMC and CAP as non-enteric and enteric coats was also vestigated. Commercial pancreatin containing tablets from ’Iferent sources were also selected in this study for compa¬rison. The enzymatic degradation at the selected temperature yed the first order reaction kinetics. The degradation ate constants of enzymes in all tablet formulations were torkedly decreased with temperature lowering. Zeparox tab¬lets showed the highest degradation values, while those coa¬ted with CAP were the most stable formulations. Festavital tablets gave the highest stability data within the commercial brands. After 6 months of storage, amylase suffered greater losses of its activity than lipase specially at 50° and 37’ . K 4C tablets prepared with Avicel exhibited about 96, 21 Wd 3.6 times decrease in their degradation rate relative to
50 , 37 and 25 C, respectively
- SUSTAINED RELEASE OF DICLOFENAC SODIUM FROM DRY ADSORBED EMULSIONS
Pages 1-16, كلية الصيدلة - جامعة المنصورة, 18/12/1992
أ.د. محمد حامد زكى الشابورى
Abstract Abstract SUSTAINED RELEASE OF DICLOFENAC SODIUM FROM DRY ADSORBED EMULSIONS Sustained release W/O dry adsorbed emulsions containing diclofenac sodium were prepared. The effect of particle size, different emulsifying agents and various hydrophilic adsorbents on the sustained release characteristics of diclo¬fenac sodium was studied. The drug release from dry adsorbed emulsions prepared with calcium stearate was slower than those prepared with Span 60. The effect of hydrophilic adso¬rbents on the drug release was found to be in the following order: Avicel PH 101 > Aerosil 200 > Avicel R.C-591. The re¬lease kinetics from the prepared particles showed that no one model was able adequately to describe the release situation.
In vivo studies using human volunteers revealed a sustained
1 I cm,
release action up to 18 hr.
- FORMULATION AND RELEASE CHARACTERISTICS OF PHENYLEPHRINE HYDROCHLORIDE SUPPOSITORIES
Pages 259-279, جامعه المنصورة - كلية الصيدلة
أ.د. خيرى السيد جبر جبر
Abd El-Gawad H. Abd El-Gawad
أ.د. محمد حامد زكى الشابورى
فهيمة هاشم - قسم الصيدلانيات- كلية الصيدلة -جامعه المنصورة
Abstract Abstract FORMULATION AND RELEASE CHARACTERISTICS OF PHENYLEPHRINE HYDROCHLORIDE SUPPOSITORIES ABSTRACT
Phenylephrine hydrochloride supposiCories were formula-
ted using Witepsols ’^35 aa<^ ^75 each alone or in
combinations of two in different ratios of 1:1, 1:2 and 2:1.
The prepared suppositoreis were evaluated for their
mechanical properties, release characteristics and drug
partitioning using different bases and water. The obtained
results re- vealed that the prepared suppositories exhibited
good mechanical properties and different
characteristics. The partition coefficient of the drug Has
found to be in a good correlation with its release profiles
from the corresponding bases. Witepsol either alone or
in combinations with £ or H, in a ratio of 2:1 (W35: ffl
or H^^) were found to be the bases of choice for formulating
phenylephrine hydrochloride suppositories referring to tneirj
good mechanical properties and high release characteristics.
The bioavailability of the drug after rectal acministratiotM
in rabbits was greater with Witepsol W.,._. over Witepsols #<cl
if. o
and H15+W35 (1:2). A highly significant in-vivo - in-vitro correlation existed.
- FORMULATION AND OCULAR DISPOSITION OF BROMHEXINE HYDROCHLORIDE OPHTHALMIC PREPARATIONS
Pages 224-238, جامعة المنصورة - كلية الصيدلة
أ.د. اسماعيل محمد اسماعيل رمضان
أ.د. محمد حامد زكى الشابورى
أ.د. يسرى السعيد محمد ابراهيم
Abstract Abstract FORMULATION AND OCULAR DISPOSITION OF BROMHEXINE HYDROCHLORIDE OPHTHALMIC PREPARATIONS ABSTRACT
3rcjn.Qe.vine hydrochloride (BE) a mucolytic agent was formulated in ophthalmic solutions, gels and ointments to be applied topically in the eyes to increase the mucus secretion in case of inflammation and keratoconjunctivitis. The effect of different ophthalmic vehicles, used in these formulation, on the in vitro release and ocular disposition of the drug in rabbit’s eye has been studied. The results obtained revealed that, gel formulations (poioxamer -:07 and sodium carboxymethyicellulose were superior to all other formulations for improving the ocular bioavailability of the drug. In case of ophthalmic solutions, the peak time was attained after one hour while the peak level was elevated in the presence cf 1% methyicellulose or polyvinyl alcohol Semisolid vehicles, gels and ointments, exhibited a sustained activity of BR as the peak time was attained after two and three hours, respectively. Highly signficant in vitro-in vivo correlations were existed.
- TN-VTTPO AND TN-VTVO EVALUATION OF SUSTAINED RELEASE FLOCTAFENINE GRANULES
Pages 239-258, جامعة المنصورة - كلية الصيدلة
أ.د. خيرى السيد جبر جبر
Abd El-Gawad H. Abd El-Gawad
أ.د. محمد حامد زكى الشابورى
فهيمه هاشم - جامعة المنصورة - كلية الصيدلة - الصيدلانيات
Abstract Abstract TN-VTTPO AND TN-VTVO EVALUATION OF SUSTAINED RELEASE FLOCTAFENINE GRANULES Abstract: Sustained release floctafenine granules contain^ stearic acid and glyceryl monostearate (matrix) were prepaid using fusion, solvent evaporation or melt granulati* techniques. The effect of Aerosil, Avicel, Emcompresa U sodium chloride as channeling agents on the in vitro relt of floctafenine was investigated. The results obtain revealed that, granules prepared by fusion method achim sustained release pat terns chan those prepared by the techniques. Moreover, ail the selected channeling t increased the extent of drug release but with different ti depending upon their concentration and nature. The re of drug was found to follow the Higuchi model with gr containing 0 and 5% channeling agents while it folio* first order kinetics with chose containing 201. Ii studies in humans revealed that the urinary excreti floctafenine from the tested granules occurred OV sustained period from 3 to 10 hr.
- EFFECT OF STRESS STORAGE CONDITIONS ON THE PHYSICAL CHARACTERISTICS AND DISSOLUTION PROFILES OF THIAMINE HYDROCHLORIDE AND FERROUS FUMARATE TABLETS
Pages 102-125, جامعة المنصورة -كلية الصيدلة
أ.د. أحمد طلعت ابراهيم نوح
Abd El-Gawad H. Abd El-Gawad
أ.د. محمد حامد زكى الشابورى
توحيدة خليل - جامعة المنصورة - كلية الصيدلة - قسم الصيدلانيات
Abstract Abstract EFFECT OF STRESS STORAGE CONDITIONS ON THE PHYSICAL CHARACTERISTICS AND DISSOLUTION PROFILES OF THIAMINE HYDROCHLORIDE AND FERROUS FUMARATE TABLETS ABSTRACT
The aging of thiamine hydrochloride and ferrous fuaal rate tablets prepared by direct and wet granulation tech-’: nique using span 40, stearic acid or PEG 6000 as granule.-, ting agents were studied under four sets of storage cond-\ itions (52% and 95% relative humidity at 25°and 45°C). The physical properties and dissolution profiles of the tablets were evaluated periodically over 6 months. The results obtained revealed that, there was a marked incre¬ase in tablet weight, friability and disintegration time; while a significant decrease in hardness and dissolution rate was observed in all tablet formulations under all the selected storage conditions. At 95% RH, thiamine hydrochloride tablets prepared with span 40 or PEG 6000 were swelled or completely deformed after 2 months.
These results pointed out that the tested tablets should be protected from moderate and higher temperature”, and humidity in order to maintain acceptable product quai lity throughout their shelf life.
- APPLICATION OF FACTORIAL DESIGN OF EXPERIMENTS TO PREDICT THE CHEMICAL STABILITY OF FERROUS FUMARATE AND THIAMINE HYDROCHLORIDE TABLETS
Pages 130-150, جامعة المنصورة - كلية الصيدلة
Abd El-Gawad H. Abd El-Gawad
أ.د. محمد حامد زكى الشابورى
Abstract Abstract APPLICATION OF FACTORIAL DESIGN OF EXPERIMENTS TO PREDICT THE CHEMICAL STABILITY OF FERROUS FUMARATE AND THIAMINE HYDROCHLORIDE TABLETS ABSTRACT
In this investigation factorial design of experiment of the type N = 2^ was applied to predict the chemical stability of ferrous fumarate and thiamine hydrochloride in tablets prepared by direct and wet granulation techniques, using Span 40, stearic acid and PEG 8000 as granulating agents. The quantitative factors were the temperature, hum¬idity and time, corresponding to the accelerated storage conditions which are 52% and 95% relative humidity at two temperature levels (25° and 45°C). The effect of the three operating factors and their interactions on the stability of both drugs as well as the derivation of imperical regres-sion equations were determined. The derived regression equations have the ability to predict the chemical stability of ferrous fumarate and thiamine hydrochloride tablets at any particular conditions within the limits specified. In addition, the coefficients of the factors and their inter¬actions were found to have negative signs, which indicated that the effect of each factor was dependent on the level of the other two factors. The obtained results revealed thai, there was very good agreement between the predicted . and the experimental data obtained from the classical design of the experiments, carried out under the specified storage conditions. The reaction rate constants and tan„ of ferrous fumarate and thiamine hydrochloride tablets determined from
- CAL STABILITY OF THIAMINE HYDROCHLORIDE AND 5 FLW\RATE IN TABLETS PREPARED BY DIRECT AND WET GRANULATION TECHNIQUES
Pages 111-129, جامعة المنصورة -كلية الصيدلة
أ.د. أحمد طلعت ابراهيم نوح
توحيده خليل خليل جوده
Abd El-Gawad H. Abd El-Gawad
أ.د. محمد حامد زكى الشابورى
Abstract Abstract CAL STABILITY OF THIAMINE HYDROCHLORIDE AND 5 FLW\RATE IN TABLETS PREPARED BY DIRECT AND WET GRANULATION TECHNIQUES ABSTRACT
• chemicaI stability of thiamine hydrochloride and wfwncrate in tablets prepared by direct granulation Its vising Span 40, stearic acid or PEG 6000 as gran-agents were studied in comparison with those pre-ifret granulation technique. Batches of tablets id good physical and mechanical properties were for this study. The stability testing was carried 5 and 95% relative humidity at two temperature and 45°C. The results obtained revealed that, iOf degradation of either thiamine hydrochloride us fumarate was increased as the relative humidity erature were increased. In case of thiamine hydro-i tablets, the highest stability data were obtained bleis prepared with stearic acid followed by those ttith PEG 3000. In case of ferrous fumarate the lability data were obtained from tablets prepared fic acid or Span 40. The degradation pathway of KS uas found to follow the first order kinetics
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